Human resourcing in academic libraries : the 'lady librarian', the call for flexible staff and the need to be counted

This paper reports on a recent set of research findings into human resource (HR) deployment in academic, college and national libraries in the UK and Ireland by selectively summarising these findings. The recommendations are that libraries should make available for comparison by others not only their library service provision, i.e. opening hours, but also staff provision, i.e. staffing numbers and demographics and staff deployment, with a view to benchmarking levels of flexibility. This work highlights the lack of existing benchmarking facilities in UK universities and colleges of higher education, relating to HR deployment in libraries, and recommends that Sconul extends the existing data collection in its Annual Statistical return to include this HR area

Default activity patterns at the neocortical microcircuit level

Even in absence of sensory stimuli cortical networks exhibit complex, self-organized activity patterns. While the function of those spontaneous patterns of activation remains poorly understood, recent studies both in vivo and in vitro have demonstrated that neocortical neurons activate in a surprisingly similar sequential order both spontaneously and following input into cortex. For example, neurons that tend to fire earlier within spontaneous bursts of activity also fire earlier than other neurons in response to sensory stimuli. These “default patterns” can last hundreds of milliseconds and are strongly conserved under a variety of conditions. In this paper, we will review recent evidence for these default patterns at the local cortical level. We speculate that cortical architecture imposes common constraints on spontaneous and evoked activity flow, which result in the similarity of the patterns

DNA polymerase activity in plasma from leukaemic guinea-pigs.

Measurement of DNA polymerase in leukaemic guinea-pig plasms reveals the presence of low levels of sedimentable and non-sedimentable enzymic activities. Since the sedimentable DNA polymerase is ribonuclease sensitive, uses poly(C).oligo(dG) as template, and bands in a sucrose density gradient at 1-17 g/ml it is thought to be the GPLV-associated reverse transcriptase. The soluble DNA polymerase is stimulated by ribonuclease and is probably of cellular origin

Enhancing coach-parent relationships in youth sports: increasing harmony and minimizing hassle

Frank Smoll and his colleagues should be commended on continuing to advance the worthy aim of making youth-sport participation more enjoyable. Indeed, the body of work generated by Smith and Smoll [e.g., 1], along with the more recent contributions of Cumming [e.g., 2], have been highly influential in coaching research and practice over a number of years. In this commentary, we focus on three of the five areas covered by the authors: i) the difference between youth and professional models of sport; ii) the goals of youth sports; and iii) parental responsibilities and challenges

Volume 4: Cosmopolitanisms in Muslim Contexts : Perspectives from the Past

Cosmopolitanism is a key concept in social and political thought, standing in opposition to closed human group ideologies such as tribalism, nationalism and fundamentalism. Much recent discussion of this concept has been situated within Western self-perceptions, with little inclusion of information from Muslim contexts. This volume redresses the balance by focusing attention on instances in world history when cosmopolitan ideas and actions pervaded specific Muslim societies and cultures, exploring the tensions between regional cultures, isolated enclaves and modern nation-states. Models are chosen from four geographic areas: The Swahili coast, the Ottoman empire/Turkey, Iran and Indo-Pakistan.https://ecommons.aku.edu/uk_ismc_series_emc/1005/thumbnail.jp

Prevalence of HCV NS3 pre-treatment resistance associated amino acid variants within a Scottish cohort

Background: Protease inhibitors (PI) including boceprevir, telaprevir and simeprevir have revolutionised HCV genotype 1 treatment since their introduction. A number of pre-treatment resistance associated amino acid variants (RAVs) and polymorphisms have been associated with reduced response to treatment. Objectives: We measured the prevalence of RAVs/polymorphisms in a PI treatment-naïve HCV genotype 1 Scottish cohort using Sanger sequencing. Study design: Chronically infected, treatment-naïve, HCV genotype 1 patients (n = 146) attending NHS Greater Glasgow and Clyde clinics were investigated for RAVs/polymorphisms to the PIs boceprevir, telaprevir and simeprevir. The NS3/4A region was amplified by nested polymerase chain reaction. The 1.4 kb amplified product was sequenced using an ABI 3710XL DNA sequencer. Sequence analysis was performed using web-based ReCall (beta 2.10). Amino acid positions 36, 41, 43, 54, 55, 80, 109, 122, 155, 156, 168 and 170 were analysed for RAVs/polymorphisms. Results: Overall, 23.29% (34/146) of patients had an RAV or polymorphism detected. Overall, 13.69% (20/146) of patients had HCV virus that contained the Q8 K polymorphism. Other RAVs detected were: V36 M 0.70% (1/146), V36L 0.70% (1/146), T54S 6.85% (10/146), V55A 3.42% (5/146) and V/I170A 0.68% (1/146). Four patients had dual combinations of mutations (T54S + V36L; T54S + V55A and 2 patients with T54S + Q80K). Conclusions: Q80K was the most prevalent baseline polymorphism detected in the Scottish cohort. Simeprevir treatment is not recommended in patients infected with the Q80K genotype 1a variant. This highlights the need for baseline sequencing prior to administration of this drug in this population